Cy3-UTP

2025-04-17

HotStart™ 2X Green qPCR Master Mix

2025-04-17

br Resection of DNA ends The highly conserved MRN

2025-04-17

Resection of DNA ends The highly conserved MRN/MRX complex (Mre11-Rad50-Nbs1 in metazoan; Mre11-Rad50-Xrs2 in yeast) and the Ku70/Ku80 heterodimer (hereafter referred to as Ku) are the first protein complexes to be recruited at DSBs [6]. The presence of Ku and MRN/MRX mediates the recruitment of

br Acknowledgments br Introduction Human innate immune

2025-04-17

Acknowledgments Introduction Human innate immune system provides first line of defense against multiple viral or bacterial attacks, and provides critical surveillance against oncogenic development. Evidences show that individuals with primary immunodeficiency or induced immunosuppression durin

Recent studies have demonstrated significant cross talk

2025-04-17

Recent studies have demonstrated significant cross-talk between XRCC1 (a key player in Y-27632 dihydrochloride excision repair (BER) and single strand break repair) and DDR [30], [31], [32]. ATM and DNA-PKcs are known to be involved in the phosphorylation of XRCC1 to promote BER [30], [31]. We have

In Rainey et al published the results of a

2025-04-17

In 2008, Rainey et al. published the results of a targeted compound library screen for potential inhibitors of the ATM kinase. In this study, the compound CP466722 was identified as a highly selective and rapidly reversible ATM inhibitor, which did not inhibit PI3K or related PIKK family members. Mo

Thieno-GTP

2025-04-16

N1-Propyl-Pseudo-UTP

2025-04-16

Desthiobiotin-16-UTP

2025-04-16

HotStart™ 2X Green qPCR Master Mix

2025-04-16

D-Lin-MC3-DMA

2025-04-15

Cell Counting Kit-8 (CCK-8)

2025-04-15

Concanavalin A (Con A)-HyperFluor™ 488

2025-04-15

Cy5-UTP

2025-04-15

Sulfo-NHS-Biotin A different mechanism has been suggested fo

2025-04-15

A different mechanism has been suggested for the role of TRX1 in ASK1 regulation based on disulfide bond-mediated ASK1 multimerization and its reduction through the thiol-reductase activity of TRX1 (Nadeau et al., 2007, Nadeau et al., 2009). In this model, oxidative stress induces intermolecular dis