• Very recently Niessen et al have described the resensitizing

  2024-12-23

  

  Very recently, Niessen et al. have described the resensitizing effect of MB327 on nAChR performing solid-supported membrane (SSM)-based electrophysiological experiments (Niessen et al., 2016) using plasma membrane preparations obtained from Torpedo californica. These findings validated and underline

• Flavopiridol cell cycle br Patients and Methods br Results b

  2024-12-23

  

  Patients and Methods Results Discussion Gjerdrum et al showed that Axl Flavopiridol cell cycle is required to maintain the mesenchymal-like invasiveness of metastatic breast carcinoma cells, but Axl knockdown has no effect on the cell proliferation of MDA-MB-231 cells. Mackiewicz et al als

• br Results and discussion br

  2024-12-23

  

  Results and discussion Conclusion In summary, a series of indazole-based derivatives were synthesized and SAR studies conducted, with view to the development of a novel Aurora kinases inhibitor. The carboxylic Cysteinyl leukotriene receptor antagonist group extending from the C-3 position of t

• Recent studies have indicated that V ATPase activity

  2024-12-23

  

  Recent studies have indicated that V-ATPase activity negatively regulates vacuolar fusion in vivo[17]. Since we have demonstrated that the pah1Δ lcq have a more acidic vacuolar pH than the WT cells, and the genes involved in the pump activity are upregulated compared to WT, the pah1Δ cells' acidity

• br Conflict of interest statement br Acknowledgments

  2024-12-23

  

  Conflict of interest statement Acknowledgments Introduction Cellular responses to genotoxic stress in eukaryotic cells are coordinated by members of the phosphoinositide kinase related protein kinase (PIKK) family. Two members of this family, Ataxia–Telangiectasia mutated (ATM) and ATM and

• The class C receptors also share a common agonist binding

  2024-12-23

  

  The class C receptors also share a common agonist-binding mode. In all cases, an agonist induces VFT closure by forming intermolecular bonds with surface residues in both the LB1 and LB2 domains (Geng et al., 2013, Geng et al., 2016, Kunishima et al., 2000, Muto et al., 2007, Nuemket et al., 2017, T

• In a study highlighted the usefulness

  2024-12-23

  

  In 2010, a study highlighted the usefulness of arginase-1 as a sensitive and specific marker of hepatocytic differentiation for diagnostic pathology [9]. Subsequent studies have validated the high sensitivity and specificity of arginase-1, in particular its added value in evaluating poorly different

• br Materials and methods br Results br

  2024-12-23

  

  Materials and methods Results Discussion Recently, we showed that stimulation of TRPM3 and TRPC6 channels triggers a signaling cascade leading to the activation of AP-1 [11], [12], [13], [15]. The objective of this study was to investigate whether stimulation of TRPV1 channels leads to an a

• Protein microarrays represent just one of a variety of

  2024-12-23

  

  Protein microarrays represent just one of a variety of experimental approaches that can be used to generate datasets of relevance to pathway mapping. Other approaches include protein Fluorescent cytotoxicity test profiling techniques, such as antibody arrays [29], tissue arrays [30] and 2-dimensiona

• br Findings br Discussion br

  2024-12-23

  

  Findings Discussion Conclusions Midwives were more likely to provide effective antimalaria services (including two doses of IPT during the second and third trimesters of pregnancy) to pregnant women if Conflict of interest Authors’ contributions Funding Acknowledgements Resea

• LOXs and CYPs are a series

  2024-12-21

  

  LOXs and CYPs are a series of iron-containing enzymes that metabolize arachidonic ATPase inhibitor (-)-Blebbistatin to form biologically active products, such as epoxyeicosatrienoic acids (EETs) hydroperoxyeicosatetraenoic acids (HETEs), prostaglandins, leukotrienes and thromboxanes [6]. Among thes

• The beneficial treatment with several statins

  2024-12-21

  

  The beneficial treatment with several statins have been evaluated in AD patients (Kivipelto et al., 2005), with controversial results. It has been suggested that statins slow cognitive decline in mild to moderate AD (Miida et al., 2005). Treatment with atorvastatin, combined with other medications,

• Several studies have recently used optogenetics to selective

  2024-12-21

  

  Several studies have recently used optogenetics to selectively activate various cholinergic neurons (Jiang et al., 2014). However, most do not explicitly report direct release of GABA from cholinergic fibers, with the exception of our two studies described above (Saunders et al., 2015a, Saunders et 

• Whereas more research is needed to

  2024-12-21

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Isochlorogenic acid C that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely rever

• Matrix metalloprotease inhibitors are increasingly available

  2024-12-21

  

  Matrix metalloprotease inhibitors are increasingly available and tested for other indications in clinical trials. The present study suggests that either ADAM10 or TACE inhibition alone will not maximally restore leukocyte Axl function. We found that lower doses of ADAM10/TACE inhibitors exhibit simi

14472 records 39/965 page Previous Next First page 上5页 3637383940 下5页 Last page