• br Other Functions of HCA Receptors HCA receptors

  2022-03-12

  

  Other Functions of HCA Receptors HCA receptors, in particular HCA1, are expressed in various primary tumor i thought about this 77, 78, 79. This is of interest, as most solid tumors show increased glucose uptake and lactate formation even under normoxic conditions, with lactate concentrations in

• br Concluding remarks Several orphan GPCRs

  2022-03-12

  

  Concluding remarks Several orphan GPCRs have expression profiles that indicate they are worthy of consideration as therapeutic targets. This view can be supported via various transgenic techniques, and it would be interesting to have wide-ranging phenotypic information on GPR35 knockout mice. Bas

• Introduction l Glutamate is a major excitatory neurotransmit

  2022-03-12

  

  Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is

• Besides the described effects on gross locomotor function im

  2022-03-12

  

  Besides the described effects on gross locomotor function, impairment of visuo-motor coordination and fine-motor skills like resting tremors, bradykinesia and rigidity were also investigated, reflecting on the symptomatology of Parkinson's disease in humans (Inzelberg et al., 2008). Preclinically, t

• emca br Conflict of interest br Introduction Since

  2022-03-12

  

  Conflict of interest Introduction Since its discovery in 1958 [1]the Ca2+-dependent K+ efflux in human red blood emca (RBC) (further referred to as the Gárdos effect) has been extensively studied (see 2, 3for review) and has been helpful in understanding the role of the Ca2+-activated K+ chan

• br GJs in the brain br

  2022-03-12

  

  GJs in the brain Alterations of GJs in epilepsy The role of GJ blockers and openers in epilepsy As previously known, GJ-mediated electrical coupling plays a role in the generation of highly synchronous electrical activity. The hypersynchronous neuronal activity is a significant feature of c

• In a mouse model of hyperhomocysteinemia

  2022-03-12

  

  In a mouse model of hyperhomocysteinemia (a risk factor for the development of vascular dysfunction) it has been shown that myoendothelial communication is enhanced due to increased expression of Cx37 and IK1 GKT137831 [], allowing the propagation of endothelial signals to VSMC and thereby decreasi

• Inflammatory pain is very common in the clinic

  2022-03-12

  

  Inflammatory pain is very common in the clinic. A study demonstrated that galanin was upregulated after nerve injury or inflammation (Ma and Bisby, 1997). It has been reported that galanin plays an important role in the transmission of nociceptive information in the spinal cord of rats with inflamma

• Of note the intracellular egg compartment exhibiting SA gal

  2022-03-12

  

  Of note, the intracellular egg compartment exhibiting SA-β-gal activity also exhibits lipofuscin auto-fluorescence (Fig. 6B), and it is co-stained with the lipid-specific dye SBB (Supplemental Fig. 5). On the one hand, these findings reflect the fact that the pool of yolk protein contains lipoprotei

• For functional metagenomics based gene screening the DNA lib

  2022-03-12

  

  For functional metagenomics-based gene screening, the DNA library construction approach is widely used . Fosmid and cosmid libraries are usually used to explore novel genes. Lee et al. reported that a halotolerant and protease-resistant α-galactosidase was identified from the gut metagenome of , a p

• Moreover intestinal chronic inflammation is a promoting fact

  2022-03-12

  

  Moreover, intestinal chronic inflammation is a promoting factor in the development of CRC in patients affected by inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. We have previously shown that pharmacological FXR activation via its ligand obeticolic Phosphatase Inhib

• FGF signals can be transduced to

  2022-03-12

  

  FGF signals can be transduced to the signaling cascades of RAS-MAPK or PI3K-AKT through FRS2 and GRB2, to the pathways of PKC or PKD via PLCγ and DAG, and to Ca2+-releasing cascade via PLCγ and IP3, finally affecting cellular proliferation, cellular survival, and angiogenesis [48]. By increasing syn

• Cy7 carboxylic acid (non-sulfonated) Both anxiety like behav

  2022-03-12

  

  Both anxiety-like behavior and sucrose preference/intake were reduced in GPR40/FFAR1 KO male mice, while social behavior was normal in KO mice. These findings indicate that brain GPR40/FFAR1 is involved in the modulation of anxiety- and depression-like behavior in rodents. Previous studies have demo

• br Discussion The initial reduction and

  2022-03-12

  

  Discussion The initial reduction and the subsequent increase in permeability proposes a regulatory process to control bleeding. However, following repeated injury, or during long-term presence of the inflammatory stimuli, these mechanisms may become defective and even detrimental. The expression

• We sought to deduce the role

  2022-03-11

  

  We sought to deduce the role of membrane lipid determinants on endo- and exocytosis by applying a combination of metabolic (lipid) engineering approaches and biophysical methods, e.g. classical optical imaging technologies and high-resolution time-resolved patch-clamp/capacitance measurements. The l

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