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The snapshots in Fig were taken at the
2021-10-19
The snapshots in Fig. 5 were taken at the end of the first platteau i.e. for 5 Å rmsd or 4 ns time. Thus, we can see that the state of the i-motif affects the mechanism of the G-quadruplex unfolding. At acidic pH the stiff structure of the i-motif does not affect the bottom part (the innermost) of t
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Of the cases identified herein three known and novel FGFR
2021-10-19
Of the 52 cases identified herein, three known and 11 novel FGFR fusion partners were identified. Notably, an oligomerization domain, including coiled-coil dimerization domains similar to that seen in echinoderm microtubule associated protein like 4 gene (EML4), which is the most common ALK partner
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br Conclusions Our in vitro and in vivo
2021-10-19
Conclusions Our in vitro and in vivo data collectively demonstrate that zifaxaban is effective in preventing thrombus formation via direct and specific inhibition of FXa in a dose-dependent manner. Furthermore, zifaxaban has a potency that is similar to that of rivaroxaban and shows a similar or
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WZB117 br Acknowledgements br Insulin is a vital peptide
2021-10-19
Acknowledgements Insulin is a vital peptide hormone with the exclusive capacity to regulate the blood glucose that entirely is secreting from pancreatic β cells (Kasai et al., 2014). The human insulin comprises 51 amino WZB117 residues, with a molecular mass of 5.808 kDa. INS, responsible for
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Posttraining memory facilitation by histamine infused into t
2021-10-19
Posttraining memory facilitation by histamine infused into the dorsal hippocampus was also observed in two more recently described and very important non-aversive forms of memory: object recognition (da Silveira, Furini, Benetti, Monteiro, & Izquierdo, 2013) and social recognition (Garrido Zinn et a
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It is noticeable that CO as well
2021-10-19
It is noticeable that CO as well as H. pylori suppresses apoptosis while it induces autophagy in AGS cells. The differential effects of CO on the activation of transcription factors responsible for regulating expression of apoptosis- and autophagy-related genes merit further investigation. In concl
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It has been reported that CD
2021-10-19
It has been reported that CD133+ glioma stem KT203 are resistant to temozolomide (TMZ) therapy [155]. Dose dependent TMZ treatment of CD133+ cells enhanced activities of the Notch and SHh pathways [156]. Moreover, 500 μmol/L TMZ induced a significant upregulation of Gli1, HES1 and HES5 transcripts.
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br General aspects of HDACs
2021-10-19
General aspects of HDACs General aspects of HDAC inhibitors Based on the previous elements, inhibitors designed for HDAC have in common a well-admitted pharmacophore model (Fig. 7A). This model is composed of a zinc binding group (ZBG), attached to a linker chain mimicking the lysine side cha
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br Introduction Hepatitis B virus
2021-10-19
Introduction Hepatitis B virus (HBV) infects about 2 billion people worldwide and is a leading cause of liver disease including liver fibrosis, cirrhosis and hepatocellular carcinoma (Trepo et al., 2014). Most current HBV therapies are based on nucleos(t)ide analogs and pegylated interferon alpha
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br Clinical development of anti NASH drug
2021-10-19
Clinical development of anti-NASH drug therapies The current understanding of NASH pathogenesis has led to broad efforts to target several features of the disease, alone or in combination, even in the absence of liver-guided therapies. Therefore, drug development in NASH is a rapidly changing fie
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FDA-approved Drug Library br Evasion strategies for enhanced
2021-10-19
Evasion strategies for enhanced therapeutic outcomes In order to increase AED penetration into the CNS, several strategies have been developed over the years to overcome the activity of efflux transporters, by inhibiting their function or by regulating their expression. Due to the high relevance
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Boc-Phe-Osu br Introduction L Glutamate is one of the most p
2021-10-19
Introduction L-Glutamate is one of the most prevalent excitatory signaling molecules in the central nervous system (CNS) (Salazar et al., 2016) and plays a crucial role in a variety of Boc-Phe-Osu functions such as memory and learning (Danbolt, 2001, Nedergaard et al., 2002). At elevated concentr
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Fig summarizes the results for M
2021-10-18
Fig. 1 summarizes the results for 500 μM concentration of the drugs. Action of histamine is presented for comparison. Both 1-methylhistamine and Nα-methylhistamine strongly potentiated ASIC1a responses. The concentration-dependence of action of Nα-methylhistamine was measured (Fig. 1B). Fitting by H
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br Dynamic Localization of Hippo Pathway Components
2021-10-18
Dynamic Localization of Hippo Pathway Components The observation that Wts normally localizes with an inhibitor, Jub, raised the question of how and where Wts normally becomes activated. Under conditions of pathway activation in Drosophila imaginal discs, Wts relocalized from Jub to Ex, where it i
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br Introduction Chronic hepatitis C CHC caused by hepatitis
2021-10-18
Introduction Chronic hepatitis C (CHC) caused by hepatitis C virus (HCV) infection affects approximately 170 million individuals worldwide [1]. HCV and human immunodeficiency virus (HIV) have similar routes of transmission, including blood-to-blood contact, sharing of injection equipment, and sex
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