• A model substance often used in

  2021-09-28

  

  A model substance often used in the studies of oxidative processes in erythrocytes is tert-butyl hydroperoxide (t-BHP), which, being lipophilic, passes easily across the erythrocyte membrane [9]. In erythrocytes treated with t-BHP (0.1–3mM) for less than 1h, a dramatic decline in the reduced glutath

• The RAS RAF MEK ERK pathway also known as the

  2021-09-28

  

  The RAS/RAF/MEK/ERK pathway (also known as the MAPK/ERK pathway) is one of the most important signaling pathways in PDAC. Activation of the MAPK/ERK pathway promotes PDAC growth and apoptosis resistance in response to gemcitabine [43,44]. We previously demonstrated that inhibition of GPX4 can overco

• Introduction Heme is an important small molecule and an esse

  2021-09-28

  

  Introduction Heme is an important small molecule and an essential cofactor for a variety of enzymes (George, 1948; Morrison and Stotz, 1954; Maehly, 1952; Igo et al., 1961). During cellular respiration, heme populates cytochromes and serves as an electron acceptor in the electron transport chain (M

• Interestingly systemic circulating levels of NOx

  2021-09-28

  

  Interestingly, systemic circulating levels of NOx were not dramatically increased by treatment with isosorbide mononitrate or sodium nitrite at a dose which exerted beneficial effects on the progression of PH. In line with our results, Mathew et al. [13] demonstrated that the long-acting NO donor m

• It appears that not all GPR agonists require

  2021-09-28

  

  It appears that not all GPR119 agonists require a high dose to elicit acceptable g protein coupled receptors control. According to preclinical data presented at the GTCbio Diabetes Summit, a 3mg/kg dose of AR-7947 was enough to induce similar blood glucose-lowering effects compared to those achieve

• br Indirect GLI antagonists br Direct GLI antagonists br

  2021-09-28

  

  Indirect GLI antagonists Direct GLI antagonists Concluding remarks Targeting GLI effectors represents a promising therapeutic strategy for cancer treatment. This is particularly relevant for certain tumors, such as MB, since, although classified into four distinct molecular groups (Hh- or W

• GLI proteins activate or repress transcription of their targ

  2021-09-28

  

  GLI proteins activate or repress transcription of their target genes by binding to a similar sequence motif within a cis-regulatory module (CRM) (Hallikas and Taipale, 2006, Peterson et al., 2012). Transcriptional responses to the HH pathway can be elicited either by de-repression of GLI-R or in oth

• histone methyltransferase In summary the SAR of a series of

  2021-09-27

  

  In summary, the SAR of a series of phenylpropanoic acid-free fatty histone methyltransferase receptor agonists is described which resulted in the identification of potent FFA4 agonists. The superior pharmacokinetic properties of compound led to its selection as an in vivo tool compound which affor

• On the other hand histone deacetylase inhibitors can

  2021-09-27

  

  On the other hand, histone deacetylase inhibitors can accelerate inflammation resolution by promoting the externalization of AnxA1, a main ALX/FPR2 agonist, with concomitant inhibition of cytokine gene expression in mouse macrophages [30]. Thus, our present results provide an additional mechanism, i

• A common feature of ferroptosis is the iron dependent accumu

  2021-09-27

  

  A common feature of ferroptosis is the iron-dependent accumulation of lipid-ROS and the subsequent depletion of polyunsaturated fatty Efavirenz phospholipids (PUFA-PLs) [118]. The PUFA chains of membrane lipids are more susceptible to both enzymatic and non-enzymatic oxidation, which results in PUF

• In the current study we report the properties of P

  2021-09-27

  

  In the current study, we report the properties of P. anserina mutants carrying mutations in a gene encoding the bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). This enzyme catalyzes two opposite reactions (Pilkis et al., 1995, Rider et al., 2004): synthesi

• FXa is a vitamin K

  2021-09-27

  

  FXa is a vitamin K-dependent serine protease consisting of two chains linked by a disulfide bridge. The heavy chain contains 303 tgf beta receptor inhibitor and the light chain has 139 amino acids. The catalytic triad comprised of Ser195, His57, and Asp102  exhibits the trypsin-like β-barrel struct

• Accumulating evidence suggests an important role for endothe

  2021-09-27

  

  Accumulating evidence suggests an important role for endothelin ETB receptors in renal homeostasis. ETB receptors promote vasodilation, natriuresis, and diuresis (Davenport and Maguire, 2011) and maintain renal perfusion via counterbalancing the effects of vasoconstrictors and regulation of water re

• We found statistically significant association between p HER

  2021-09-27

  

  We found statistically significant association between p95-HER2 levels and hormone receptor status, Ki-67 GDC0449 synthesis and metastatic regions (p = 0.004, best outcomes as regard OS of lapatinib therapy was recorded in patients with moderate overexpression of HER2 accompanied with high p95-HER2

• br Consequence physiological function of

  2021-09-27

  

  Consequence/physiological function of ROS-dependent inhibition of GSNOR Plants response to environmental changes induced by abiotic and biotic factors by enhanced accumulation of ROS resulting in temporary imbalance of the cellular redox homeostasis. This as oxidative stress/burst termed event tr

14439 records 563/963 page Previous Next First page 上5页 561562563564565 下5页 Last page