• Enolase is an example of a moonlighting protein that

  2021-05-28

  

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation.

• Emphysema is an important component of COPD which

  2021-05-28

  

  Emphysema is an important component of COPD, which is responsible for airflow limitation. In the present study, a significant airspace enlargement was observed 21 days after elastase administration. Interestingly, daily administration of olaparib provided greater protection against emphysema as comp

• br Orthotopic liver transplantation OLT is

  2021-05-28

  

  Orthotopic liver transplantation (OLT) is the only curative therapy available for patients with end-stage liver disease. The surgical procedure of liver transplantation inherently involves cold ischemia during graft preservation , followed by reperfusion of the transplanted graft which results in

• To predict levels of SCF assembly Liu

  2021-05-28

  

  To predict levels of SCF assembly, Liu et al. (2018) first quantified the remaining necessary kinetic parameters and derived a model in combination with known functions and concentrations of components. The model agrees astonishingly well with many experimental observables. In terms of SCF assembly,

• E ubiquitin ligases are key players in the ubiquitin proteas

  2021-05-28

  

  E3 ubiquitin ligases are key players in the ubiquitin-proteasome pathway because they catalyse ubiquitination of substrate proteins.39, 40, 41 As important regulators of cellular ubiquitination, E3 ligases are emerging as attractive drug targets, particularly in cancer.42, 43, 44 However, E3 ligases

• br Acknowledgments We thank our colleagues who have

  2021-05-28

  

  Acknowledgments We thank our colleagues who have contributed to our understanding of the Kartogenin and the structure and function of APC/C, and apologize to those whose work we were unable to cite here. We thank J. Rajan Prabu for making the movies showing APC/C conformational changes. Our work

• br Results br Discussion Taking advantage of the

  2021-05-28

  

  Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate APETx2 sale that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 interactions

• Covalent inhibitors are well suited for targeting the E enzy

  2021-05-28

  

  Covalent inhibitors are well suited for targeting the E1 cytochalasin d of Ubl modifications. Because the E1 enzymes in Ubl modifications, such as the SUMO E1 and Atg7, have a slow turnover rate (Boggio et al., 2004), prolonged inhibition can be achieved without requiring compounds to be stable in c

• To date many studies have reported significant aberrant meth

  2021-05-28

  

  To date, many studies have reported significant aberrant methylation patterns in TIMPs in various types of cancer Dihydro-β-erythroidine hydrobromide [[16], [17], [18]]. However, little has been reported on the events that lead to the methylation of TIMPs in the UV-irradiated human skin. Therefore,

• br Competing interests br Acknowledgements br

  2021-05-28

  

  Competing interests Acknowledgements Introduction Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) in biomembranes to produce phosphatidic melanocortin receptor (PA) [1], [2], [3], [4], [5], [6]. To date, ten mammalian DGK isozymes (α, β, γ, δ, ε, ζ, η, θ, ι and κ) have been

• As a functional ETC is required for

  2021-05-28

  

  As a functional ETC is required for DHODH catalysis (Loffler, Jockel, Schuster, & Becker, 1997; Rawls, Knecht, Diekert, Lill, & Loffler, 2000; Zameitat, Freymark, Dietz, Loffler, & Bolker, 2007), DHODH depends on the mitochondrial ETC to generate adequate concentrations of ubiquinone (Fig. 2). Cells

• Cell migration and invasion are central processes in the

  2021-05-28

  

  Cell migration and invasion are central processes in the development and metastasis of cancer. The regulation of cell migration by DDR1 has been reported in many types of cancer cell lines; however, conflicting results have been reported regarding the inhibitory as well as promotive effects of DDR1

• br Results and Discussion br Materials and Methods br Acknow

  2021-05-28

  

  Results and Discussion Materials and Methods Acknowledgements Introduction Among the solid tumors, Prostate cancer (PCa) has been one of the most frequently diagnosed malignancy in men and the second male's cancer related deaths in the developed countries [1]. In China, the incidence and

• Having generated synthetic cytokines and synthetic cytokine

  2021-05-28

  

  Having generated synthetic cytokines and synthetic cytokine receptors, the logical next step has been to design fully synthetic cytokine/cytokine receptor systems, modifying either cytokine/cytokine receptor binding interfaces or cytokine-unrelated combinations of substances and their binding domain

• Bearing in mind that temperamental traits are genetically

  2021-05-27

  

  Bearing in mind that temperamental traits are genetically determined, in the present study we have chosen to investigate COMT and OPRM1 gene polymorphisms related to stimulation of the nervous system, which is extremely important in combat sports. The μ-opioid receptor gene OPRM1 is located on the

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