• Malaria remains a major cause of public health

  2020-08-04

  

  Malaria remains a major cause of public health problem in about 95 countries mainly located in the tropical zone of the globe (notably Africa, South-East Asia and also Eastern Mediterranean region). This parasitic disease is still estimated to affect over 212 million people and accounted for 429,000

• Culture conditions particularly temperature which affect the

  2020-08-03

  

  Culture conditions (particularly temperature), which affect the pathogenicity of Y. enterocolitica (Bottone, 1997), may also impact its inhibitory properties against cysteine proteases. However, culturing the bacterial strains at 37 instead of 28 °C did not alter remarkably the inhibitory potential

• In order to unravel patho physiological

  2020-08-03

  

  In order to unravel (patho-)physiological mechanisms involving oxysterols, it is crucial to elucidate the underlying formation and degradation of oxysterols and to uncover their intracellular and tissue-specific site of metabolism. Whereas the formation of 7α25OHC involves two hydroxylation steps fr

• The importance of EBI for B cell function was first

  2020-08-03

  

  The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed dopamine receptors and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involvemen

• br STAR Methods br Acknowledgments We

  2020-08-03

  

  STAR★Methods Acknowledgments We would like to thank the DNA cloning, Protein Production, DNA sequencing facility, and mass spectrometry teams of the MRC Protein Phosphorylation and Ubiquitylation Unit for their support. We would like to thank Prof. Dario Alessi, Prof. Ronald Hay, Prof. Philip

• Interestingly several ES cell lines are null for

  2020-08-03

  

  Interestingly, several ES cell lines are null for p53, possibly because the EWS-FLI1 chimeric protein can directly and indirectly interfere with p53 activity [38], [39]. The inhibition, loss and/or mutation of p53, one of the most common events in tumorigenesis, results in a decreased oxygen consum

• PD-1/PD-L1 Inhibitor 3 The hemiketal complex formed by

  2020-08-01

  

  The hemiketal complex formed by acetophenones with cholinesterases is analogous to the tetrahedral transition state intermediate formed during the hydrolysis of ester substrates like acetylcholine, and enzyme stabilization of this complex promotes catalytic hydrolysis. Since all the acetophenone com

• Despite the differences in the clustering abilities of DDR

  2020-07-31

  

  Despite the differences in the clustering abilities of DDR1b versus DDR2 upon ligand administration, we also noted striking similarities in the spatial distribution and phosphorylation of DDR1b-YFP and DDR2-GFP. We show for the first time that in MC3T3-E1 cells, after 4 h of collagen administration,

• Similar to PGD nearly all of the CRTH antagonists

  2020-07-31

  

  Similar to PGD2, nearly all of the CRTH2 antagonists are carboxylic Licofelone derivatives with a carboxylate moiety, which is believed to be a critical pharmacophore that interacts with the receptor (Pettipher and Whittaker, 2012) (Figure 1A). To understand the molecular mechanisms for the action

• Recruitment of plasminogen on to the bacterial surface

  2020-07-31

  

  Recruitment of plasminogen on to the bacterial surface has long been acknowledged as a mechanism involved in bacterial attachment and tissue invasion [6], [7], [8]. Plasminogen is a proenzyme which can be proteolytically activated by host tissue plasminogen activator (tPA) and urokinase into fibrino

• br Conclusions br Declaration of interest br Acknowledgement

  2020-07-31

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• Although Bach is expressed in diverse cell

  2020-07-31

  

  Although Bach1 is expressed in diverse cell types, no clear defects are observed in Bach1-deficient mice under normal conditions [10]. Bach1-deficient mice also exhibit elevated disease tolerance in various models, including atherosclerosis in ApoE double-knockout mice [38], lung damage after high o

• br Material methods br Results br Discussion In the present

  2020-07-31

  

  Material & methods Results Discussion In the present study, male zebrafish of the AB line were classified as bold and shy, respectively, based on activity and risk-taking behavior in the novel tank diving test, and extreme bold and shy individuals were selected for analysis of whole Puromyc

• br Results br Discussion TLS is

  2020-07-31

  

  Results Discussion TLS is an essential biological process that allows both prokaryotic and eukaryotic 234 2 to cope with unrepaired DNA lesions. While it is clear that TLS is important for maintaining cell viability, the molecular mechanisms accounting for how certain DNA polymerases efficient

• Taking a pragmatic approach with

  2020-07-31

  

  Taking a pragmatic approach with a view to complete the study and because chemotherapy regimens in NETs are not standardized, we do not impose a specific regimen in both arms. However, one regimen in each arm is recommended in order to reduce heterogeneity: the ALKY-based chemotherapy arm will recei

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