• br COTSget based Architectures This section describes how

  2019-09-17

  

  COTSget-based Architectures This section describes how our COTSget-based architectures are defined. We use a design inspired by MDE to build a Domain-Specific Language (DSL) of the architecture, as can be seen in the metamodel of Fig. 3. This metamodel defines the abstract syntax of our DSL and i

• Synthetic progestogens also known as synthetic

  2019-09-16

  

  Synthetic progestogens (also known as ‘synthetic gestagens’, ‘synthetic progestins’ or simply ‘progestins’) are designed to mimic the effects of progesterone (P4) and are the active pharmaceutical ingredient in many contraceptives and hormone replacement therapies. Since most progestins are derived

• Our study shows that deletion of Dpf

  2019-09-16

  

  Our study shows that MRE 3008F20 of Dpf2 in mouse ESCs decreased their self-renewal ability and dramatically impaired their differentiation into mesoderm and endoderm while promoting neural ectoderm differentiation. The differentiation defect to meso-endoderm could be rescued by restoring Tbx3 leve

• Interestingly several ES cell lines are null

  2019-09-16

  

  Interestingly, several ES cell lines are null for p53, possibly because the EWS-FLI1 chimeric protein can directly and indirectly interfere with p53 activity [38], [39]. The inhibition, loss and/or mutation of p53, one of the most common events in tumorigenesis, results in a decreased oxygen consump

• br Materials and methods br Results

  2019-09-16

  

  Materials and methods Results Discussion COX-2-mediated production of PGE2 is involved in cell growth and metastasis of many cancers. Previous studies indicated that COX-2 was overexpressed in many cancer tissues and that PGE2 increased cancer cell growth, a process that could be suppressed

• The strand domain swap in the UbV

  2019-09-16

  

  The β strand domain swap in the UbV.XR dimer appears to be a unique arrangement for a Ub-based dimer. In solution, free Ub has a KD of ∼5 mM for the monomer-dimer equilibrium, and the two subunits in the dimer adopt a range of relative orientations involving residues from Ub’s β sheet (Liu et al., 2

• As small non coding RNAs microRNAs miRNAs can control gene

  2019-09-16

  

  As small non-coding RNAs, microRNAs (miRNAs) can control gene expression at the post-transcriptional level by binding to the 3′-untranslated regions (3′-UTR) of messenger RNAs (mRNA) [15], [16]. miRNAs have been anticipated to regulate virtually all cellular mechanisms [17] and to play an important

• ritanserin br Conflict of interest br Acknowledgements This

  2019-09-16

  

  Conflict of interest Acknowledgements This work was funded by the National Science Centre, Poland, grant number N N303 571539. We are greatly indebted to Patrick Fox for help with the final manuscript. Introduction Alkylating agents which interact directly with DNA to form covalent bonds h

• Primary human GBM neurospheres expressed high levels

  2019-09-16

  

  Primary human GBM neurospheres expressed high levels of the metabolic enzyme fatty acyl-CoA synthetase VL3 (ACSVL3) that were associated with CSCs self-renewal and tumorigenic capacity. ACSVL3 knockdown significantly decreased ALDH levels, indicating its contribution to cell metabolism and maintenan

• Although further experiments are needed

  2019-09-12

  Although further experiments are needed to determine definitively whether D–ETB receptor heterodimers exist, for example, by using fluorescence resonance H-1152 transfer analysis or co-immunoprecipitation of receptors, the results of the study by Zeng and colleagues appear to indicate that D–ETB receptor interactions in the renal tubules facilitate D agonist-induced natriuresis.

• GS-9620 Method Results Discussion In

  2019-09-11

  Method Results Discussion In this cross-sectional study, we investigated the relationship between the COMT ValMet polymorphism and age on regional cortical thickness in healthy adults across the lifespan.

• Fluvastatin Our previous work has demonstrated that two glut

  2019-09-10

  Our previous work has demonstrated that two glutamate residues (Glu-305 and Glu-331 in murine and human TPP II) in the active site are important for exopeptidase activity in mTPP II [17].

• Secondary and primary studies have considered the decision

  2019-09-09

  Secondary and primary studies have considered the decision to select the provider and to select components after the component origin is chosen.

• Eldecalcitol A factor that complicates the use of human live

  2019-09-07

  A factor that complicates the use of human liver Eldecalcitol is one of variability, which arises in part because many of the human liver samples available for research show various stages of a variety of disease states (steatosis (fatty liver), cirrhosis, carcinogenesis in adjacent tissue), although care is taken to avoid liver infected with hepatitis, HIV or other potentially infectious agents.

• Conclusion Acknowledgements

  2019-09-06

  Conclusion Acknowledgements Introduction In recent years, fast progress has been made toward using the supercritical technology in industrial separation processes.

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